Detalhe da pesquisa
1.
G-Quadruplexes as Key Transcriptional Regulators in Neglected Trypanosomatid Parasites.
Chembiochem
; 24(12): e202300265, 2023 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37146230
2.
Structure-activity relationship of dibenzylideneacetone analogs against the neglected disease pathogen, Trypanosoma brucei.
Bioorg Med Chem Lett
; 81: 129123, 2023 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36608774
3.
Arylboronic acids as dual-action FAAH and TRPV1 ligands.
Bioorg Med Chem Lett
; 26(5): 1401-5, 2016 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26850005
4.
Evaluation of the analgesic effect of 4-anilidopiperidine scaffold containing ureas and carbamates.
J Enzyme Inhib Med Chem
; 31(6): 1638-47, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27063555
5.
Structure-Activity Relationships, Tolerability and Efficacy of Microtubule-Active 1,2,4-Triazolo[1,5- a ]pyrimidines as Potential Candidates to Treat Human African Trypanosomiasis.
bioRxiv
; 2023 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36945407
6.
Structure-Activity Relationships, Tolerability and Efficacy of Microtubule-Active 1,2,4-Triazolo[1,5-a]pyrimidines as Potential Candidates to Treat Human African Trypanosomiasis.
ChemMedChem
; 18(20): e202300193, 2023 10 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37429821
7.
G-quadruplexes Mark Sites of Methylation Instability Associated with Ageing and Cancer.
Genes (Basel)
; 13(9)2022 09 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36140833
8.
Long-range DNA interactions: inter-molecular G-quadruplexes and their potential biological relevance.
Chem Commun (Camb)
; 58(92): 12753-12762, 2022 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36281554
9.
From rational design to serendipity: Discovery of novel thiosemicarbazones as potent trypanocidal compounds.
Eur J Med Chem
; 244: 114876, 2022 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36343429
10.
Structure-Based Optimization of Quinazolines as Cruzain and TbrCATL Inhibitors.
J Med Chem
; 64(17): 13054-13071, 2021 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34461718
11.
Congeners Derived from Microtubule-Active Phenylpyrimidines Produce a Potent and Long-Lasting Paralysis of Schistosoma mansoni In Vitro.
ACS Infect Dis
; 7(5): 1089-1103, 2021 05 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33135408
12.
Evaluation of the Structure-Activity Relationship of Microtubule-Targeting 1,2,4-Triazolo[1,5-a]pyrimidines Identifies New Candidates for Neurodegenerative Tauopathies.
J Med Chem
; 64(2): 1073-1102, 2021 01 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33411523
13.
Identification of anisomycin, prodigiosin and obatoclax as compounds with broad-spectrum anti-parasitic activity.
PLoS Negl Trop Dis
; 14(3): e0008150, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32196500
14.
Brain-Penetrant Triazolopyrimidine and Phenylpyrimidine Microtubule Stabilizers as Potential Leads to Treat Human African Trypanosomiasis.
ChemMedChem
; 13(17): 1751-1754, 2018 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29969537
15.
Multitargeted Imidazoles: Potential Therapeutic Leads for Alzheimer's and Other Neurodegenerative Diseases.
J Med Chem
; 60(12): 5120-5145, 2017 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28530811
16.
Evaluation of Oxetan-3-ol, Thietan-3-ol, and Derivatives Thereof as Bioisosteres of the Carboxylic Acid Functional Group.
ACS Med Chem Lett
; 8(8): 864-868, 2017 Aug 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28835803
17.
Discovery of 1,1'-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors.
J Med Chem
; 58(21): 8564-72, 2015 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-26497049
18.
New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer.
J Med Chem
; 58(15): 5789-807, 2015 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26132075